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ORIGINAL ARTICLE
Year : 2014  |  Volume : 42  |  Issue : 2  |  Page : 74-78

Antipyretic effect of ethanolic extract of Moringa oleifera leaves on albino rats


1 Department of Pharmacology, IMS and SUM Hospital, Bhubaneswar, Odisha, India
2 Department of Anatomy, IMS and SUM Hospital, Bhubaneswar, Odisha, India
3 Department of Pharmacology, SPS, Siksha O Anusandhan (SOA) University, Bhubaneswar, Odisha, India

Correspondence Address:
Ayon Bhattacharya
Department of Pharmacology, IMS & SUM Hospital, Kalinga Nagar, B.O. Ghatikia, Bhubaneswar 751003, Odisha
India
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DOI: 10.4103/1110-1415.137810

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Objective The aim of the study was to evaluate the antipyretic activity of ethanolic leaf extract of Moringa oleifera using Brewer's yeast-induced pyrexia model. Materials and methods It was a randomized controlled experimental study. A total of 60 rats were taken, dividing them in six groups, each containing 10 rats. Ethanolic extract of M. oleifera (EMO) was administered at 50, 100, 200, and 400 mg/kg doses orally to the respective four groups. The control group was fed with normal saline at 2 ml/kg. A 20% suspension of Brewer's yeast in normal saline was injected subcutaneously at a dose of 10 ml/kg body weight below the nape of neck of rats in all groups. Pyrexia developed after 10 h of Brewer's yeast injection and the temperature was recorded. Animals which showed a rise in body temperature to at least 39°C were included in the study, allowing a minimal of six rats in each group, total of 36 rats. Drugs were given after development of pyrexia and temperatures were recorded. Paracetamol at 100 ml/kg orally was taken as the standard drug. Results The ethanolic leaf extract of M. oleifera showed significant (P < 0.05) antipyretic activity at 100, 200, and 400 mg/kg. Paracetamol showed significant antipyretic activity from 15 min of drug administration to 12 h. EMO at a dose of 50 mg/kg did not show antipyretic effect. The onset of action of EMO 100 mg/kg was found to be 2 h and that of 200 and 400 mg/kg was found to be 30 min. For all the doses, the antipyretic effect lasted up to 12 h. Conclusion The ethanolic leaf extract of M. oleifera exhibited significant (P < 0.05) antipyretic activity at 100, 200, and 400 mg/kg.


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