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Year : 2015  |  Volume : 43  |  Issue : 1  |  Page : 22-27

Biochemical markers for early detection of cardiovascular disorders in rheumatoid arthritis

1 Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt
2 Department of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt
3 Department of Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta, Egypt

Correspondence Address:
Abeer A Abo Zeid
Department of Physiology, Faculty of Medicine, Tanta University, Tanta
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DOI: 10.4103/1110-1415.154562

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Background The mechanism of accelerated atherosclerosis accompanied with rheumatoid arthritis (RA) remains unclear. Aim The aim of this study was to investigate the association between fetuin-A, asymmetric dimethylarginine (ADMA), advanced oxidation protein products (AOPPs), and accelerated atherosclerosis in patients with RA, for early detection of cardiovascular disorders. Patients and methods This study was carried out on 60 participants: 40 RA patients and 20 healthy volunteers of similar age and sex. Assessment of Disease Activity for 28-Joint Indices Score and ultrasonographic examinations of carotid intimal thickness and stiffness parameter β were carried out. In addition, lipid profile, serum high-sensitivity C-reactive protein, ADMA, fetuin-A, and AOPPs levels were measured in all participants. Results There was a significant increase in serum ADMA and AOPP levels in RA patients compared with controls. Serum fetuin-A levels were lower in RA patients than in controls. There was a positive correlation between serum ADMA levels and serum erythrocyte sedimentation rate, high-sensitivity C-reactive protein, rheumatoid factor, Disease Activity for 28-Joint Indices Score, carotid intima-media thickness, stiffness index β, total cholesterol, low-density lipoprotein cholesterol, triglyceride levels, and total cholesterol/high-density lipoprotein cholesterol and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratios. Conclusion Low levels of fetuin-A, in RA, suggest its possible contribution in the pathophysiology of endothelial dysfunctions, subsequently causing increase in arterial stiffness. An increase in ADMA and AOPPs in RA patients, together with dyslipidemia, suggests their possible involvement in the physiology and pathophysiology of vascular diseases in RA. These findings open new avenues for further studies on the physiology of cardiovascular diseases in RA that may lead to a better treatment of these diseases.

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