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ORIGINAL ARTICLE
Year : 2015  |  Volume : 43  |  Issue : 4  |  Page : 127-133

Effect of proton pump inhibitor and voice therapy on reflux-related laryngeal disorders


1 Department of Otorhinolaryngology, Sohag University, Sohag, Egypt; Department of Phoniatrics, King Fahd Hospital Jeddah, Jeddah, Kingdom of Saudi Arabia
2 Department of Otorhinolaryngology, El-Minia University, Minya, Egypt

Correspondence Address:
Hatem Ezzeldin
(Phoniatrics), Department of Phoniatrics, King Fahd Hospital Jeddah, PO Box 8488, Jeddah 21196

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DOI: 10.4103/1110-1415.168728

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Objectives The aim of this study was to evaluate the effect of proton pump inhibitor (PPI) in combination with voice therapy (VT) in the treatment of patients with laryngopharyngeal reflux (LPR) and to evaluate the efficacy of 3-month treatment. Study design This was a prospective comparative study. Patients and methods A total of 50 patients having different symptoms of LPR were included. The reflux symptom index and reflux finding score were used to diagnose LPR. The patients were classified into two groups: group A patients were treated with omeprazole and VT, and group B patients were treated with omeprazole alone. The patients were followed up for 3 months. Acoustic analysis of voice and the voice handicap index were used to compare both groups. Results Laryngeal findings found in participants of this study were as follows: laryngeal erythema (28%) and posterior commissure hypertrophy and granulation tissue, which represented 16% each. Subglottic edema, ventricular obliteration, diffuse laryngeal edema, and thick endolaryngeal mucus were also observed. Results of acoustic correlates of dysphonia (Jitter, Shimmer, and harmonic-to-noise ratio) and voice handicap index showed significant improvement after 3 months of using PPI. However, marked improvement was observed in patients who received both PPI and VT together. Conclusion PPI in combinations with VT was more effective in alleviating laryngeal manifestations in patients with LPR compared with PPI alone. The duration of 3 months was sufficient to improve symptoms and manifestations in both groups.


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