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Year : 2018  |  Volume : 46  |  Issue : 4  |  Page : 281-287

Evaluation of the role of mast cell tryptase in the pathogenesis of skin tags

1 Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt
2 Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt

Correspondence Address:
MD Ghada F.R Hassan
1 Asmaa Bent Abi-Bakr Street, Neseem Street, End of Moheb Street, Al-Mahalla Al-Kobra, El-Gharbia Governorate, 31111
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DOI: 10.4103/tmj.tmj_16_18

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Background Skin tags (STs) are considered as common benign tumors of the skin. They are made of loose fibrous tissue and occur mainly on flexures and neck as protrusions that are soft and pedunculated. The etiopathogenesis of STs is not well understood yet. Mast cells (MCs) have been found to promote fibrosis and collagen deposition through tryptase, which is one of their mediators. So, there may be a link between MCs activation and STs formation. Aim The aim of this study was to evaluate tryptase from MCs and its possible role in the pathogenesis of STs. Patients and methods This study was carried out on 40 patients having STs. They were subjected to clinical examination, dermatological examination, and routine investigations. Moreover, skin biopsies were taken from STs from all 40 patients and from normal skin of 20 of these patients to act as a control group. All biopsies were stained by MC tryptase to study the count of MCs in controls as well as STs. Results STs had significantly higher MC counts compared with control skin. A significant positive correlation was found between MC count and serum triglycerides. A significant positive correlation between number of STs and age of the patients, BMI, and triglycerides was elicited. Obese and overweight patients showed higher MC count than normal weight patients. Thighs, axillae, and neck showed higher MC count compared with other sites, despite the relation between them being not significant. Conclusion MCs and their product tryptase are overexpressed in STs and may have an essential role in its pathogenesis.

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