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  Citation statistics : Table of Contents
   2014| July-September  | Volume 42 | Issue 3  
    Online since October 29, 2014

 
 
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ORIGINAL ARTICLES
Obestatin and l-carnitine as a defensive strategy against fertility disorders induced by obesity in male rats
Magdi A El-Damarawi, Mahmoud E Salama
July-September 2014, 42(3):103-111
DOI:10.4103/1110-1415.143565  
Aim This study was designed to investigate the usage of obestatin (OB) and l-carnitine (LC) as a defensive strategy against fertility disorders induced by obesity in male rats. Materials and methods The study was carried out on 50 male Wistar rats, which were divided into five groups as follows: the control group, untreated obese rats, obese rats treated with OB, obese rats treated with LC, and obese rats treated with both OB and LC. Results The induction of obesity resulted in significant increase in body weight, plasma level of triglyceride, total cholesterol, low-density lipoprotein-cholesterol, and thiobarbituric acid reactive substance as compared with the control group. In addition, it produced significant lower activities of superoxide dismutase, catalase, and glutathione peroxidase antioxidant enzymes (GHP-Px) in testicular tissue. There was reduced plasma testosterone, follicle stimulating hormone, luteinizing hormone, and low-density lipoprotein-cholesterol and decreased sperm count and motility. OB significantly lowers body weight, plasma levels triglyceride, total cholesterol, low--density lipoprotein-cholesterol, and testicular thiobarbituric acid reactive substance level. These changes were coupled with significant increase in antioxidant enzymes activities in testicular tissue with significant increase in testosterone plasma level and sperm count and motility. This was accompanied by insignificant increase in plasma follicle stimulating hormone and luteinizing hormone levels. LC produced similar but better changes in all parameters except body weight. Moreover, the concomitant administration of both OB and LC to obese rats resulted in more improvement in all parameters than that were noticed in group III or IV. Conclusion The results of the study verified the possible combined use of OB and LC as a defensive strategy against fertility disorders induced by obesity. OB has the upper hand as anorexigenic agent, whereas LC is superior against obesity as a case of secondary hypogonadism.
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A comparative study of Duplex Doppler ultrasound and blood indices as noninvasive predictors of oesophageal varices in cirrhotic patients
Mona Shehata, Lobna A AboAli, Khalid El-Shafey, Marwa El-Hossary
July-September 2014, 42(3):83-91
DOI:10.4103/1110-1415.143552  
Background Endoscopic surveillance of oesophageal varices (OV) in cirrhotic patients is expensive and uncomfortable for the patients. Therefore, there is a particular need for noninvasive predictors for OV. Objective The aim of the present study was to evaluate the accuracy of ultrasound indices and blood indices as noninvasive OV predictors among cirrhotic patients. Patients and methods A total of 61 cirrhotic patients were enrolled in this study and were divided into two groups: 21 patients without OV and 40 patients with OV who were further subdivided into 24 patients with small OV and 16 with large oesophageal varices (LOV). P2/MS, serum fibrosis markers (APRI, FIB4, Lok score, and Forns index), abdominal ultrasonography [portal vein diameter (PVD), splenic index], platelet count/spleen diameter ratio (PC/SD), and Doppler ultrasonography [portal vein velocity, splenoportal index, hepatic and splenic impedance indices, and hepatic venous waveform (HVWF)] were assessed in all patients. Results P2/MS was the best predictor of OV and LOV [area under the curve (AUC) 0.88 and 0.787, respectively] followed by PC/SD (AUC 0.77 and 0.715, respectively). PVD, serum fibrosis markers, and serum albumin had the least accuracy for OV prediction. For LOV predictions, Lok score had good accuracy (AUC 0.785) followed by serum albumin, PVD, APRI, and Forns index (AUC 0.72, 0.738, 0.734, and 0.738, respectively). Monophasic HVWF showed a good positive predictive value (85%) and specificity (80.95%) for prediction of OV and good sensitivity (81.25%) and negative predictive value (81.25%) for LOV. Conclusion P2/MS can identify OV and LOV in cirrhosis with high accuracy followed by PC/SD. Monophasic HVWF is a good noninvasive predictor of OV and LOV in cirrhotic patients.
  1 2,566 244
CASE REPORTS
Mucormycosis of the hard palate: a rare case report
Atul Jain, Rachana Jain, Iqbal M Banyameen, Trupti Shetty
July-September 2014, 42(3):112-114
DOI:10.4103/1110-1415.143566  
Mucormycosis is a rare but aggressive opportunistic fungal infection. Mucormycosis refers to several different diseases; the causative agents of mucormycosis are the filamentous fungi of the Mucoraceae family, of the order Mucorales. Here, we report a case of mucormycosis in the hard palate of a 46-year-old woman without any predisposing factors. For early diagnosis of mucormycosis, histopathological examination is essential. In the present case, the fungus was identified by hematoxylin and eosin staining and confirmed by PAS and Grocott's silver methenamine special staining. As mucormycosis occurs infrequently, it may pose a diagnostic and therapeutic dilemma to those who are not familiar with its clinical presentation. The patient was successfully treated with a combination of surgical debridement and amphotericin-B. Through this case report, we would like to emphasize that mucormycosis of the hard palate occurs even in immunocompetent patients.
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An unusual case of erupted compound odontoma: What happens when it erupts?
Prasanna Kumar Rao, Laxmikanth Chatra, Prashanth Shenai, KM Veena, Rachana V Prabhu, Tashika Kushraj, Prathima Shetty, Vishnudas Prabhu
July-September 2014, 42(3):115-117
DOI:10.4103/1110-1415.143570  
Odontomas are benign odontogenic tumors of epithelial and mesenchymal origin. They are considered as hamartomas rather than true neoplasms. They are asymptomatic, slow growing, nonaggressive and are composed of dental tissues. They are commonly associated with tooth eruption disturbances and are discovered on routine radiographic examination. Erupted odontomas are rare entities in the oral cavity. Here, we report an unusual case of erupted odontoma.
  - 1,946 132
ORIGINAL ARTICLES
Stented versus nonstented open pyeloplasty for primary ureteropelvic junction obstruction in children
Akram M Elbatarny, Mahmoud A Elafifi, Amel A Hashish, Ahmed M Elsharaby
July-September 2014, 42(3):92-97
DOI:10.4103/1110-1415.143555  
Purpose The aim of the study was to compare the short-term results of stented versus nonstented open Anderson-Hynes dismembered pyeloplasty regarding operative time, hospital stay, functional outcome, and complications. Patients and methods Twenty-seven pediatric open Anderson-Hynes dismembered pyeloplasties were performed for primary pelviureteric junction obstruction (PUJO) by a single team at a single institution from November 2009 to October 2012. Preoperative investigations included renal function tests, urine microscopy, culture, and sensitivity, renal ultrasonography, and diethylenetriamine pentaacetic acid (DTPA). Patients were simply randomized into two groups: group I, the stented group (either nephrostent or JJ stent), and group II, the nonstented group. Outcome was analyzed with respect to operative time, hospital stay, postoperative complications, postoperative effect on hydronephrosis, and postoperative differential renal function (DRF). Minimal follow-up was 6 months. Results This study included 27 pediatric patients with primary PUJO, 14 patients in group I and 13 patients in group II. The mean age was 5.7΁2.6 years. Twelve (44.4%) cases were right sided and 15 (45.6%) were left sided; no bilateral cases were present. The mean DRF preoperatively was good in both groups (37.5% for group I vs. 35.6% in group II). There was no significant difference in operative time between both groups. The hospital stay was significantly shorter in the stented group, but this was mainly related to postoperative care policy in both groups. There was no significant difference between both groups regarding the complication rate. Postoperative DRF as well as hydronephrosis were significantly improved in both groups, but there was no statistically significant difference between both groups. Conclusion The use of stents in pyeloplasty is not justified as a routine. The overall success and complication rates are independent of whether or not to drain or of the method of drainage. Therefore, it seems that the choice depends on local circumstances and surgeon preference. A larger number of patients is needed to validate these results.
  - 2,520 190
Preoperative evaluation of colorectal carcinoma by multislice computed tomography
Aly A Elbarbary, Manal E Badawy
July-September 2014, 42(3):98-102
DOI:10.4103/1110-1415.143562  
Objective The purpose of this study was to assess the role of multislice computed tomography (MSCT) in preoperative evaluation of colorectal carcinoma (CRC) and to compare the imaging findings with surgical/pathological findings. Patients and methods MSCT scan was performed for 44 patients with pathological proven CRC. All these patients underwent spiral computed tomography with oral and intravenous contrast administration. Surgery was subsequently performed in all patients and surgical specimens were sent for detailed pathologic analysis. The MSCT assessment was then compared with the histopathological findings for sensitivity, specificity, and accuracy. Results MSCT had 60% sensitivity and 83% specificity for assessment of local spread of disease, 69% sensitivity and 76% specificity for the evaluation of lymph nodal metastases, and 89% sensitivity and 96% specificity for hepatic metastases. In all cases, the visualized tumor growth with wide zone of resection and regional nodal chains were surgically removed. It was, however, the distant metastases that made a difference to the type of curative or palliative surgery planned, and in this study spiral computed tomography had 92% accuracy for detection of hepatic metastases. Conclusion MSCT has a significant role in preoperative evaluation and subsequent management of CRC.
  - 1,931 153